Investigation of Antiproliferative, Apoptotic and Antioxidant Effects of Oleuropein and Vitamin D on Breast Cancer Cell Lines (MCF-7)

Abstract

Breast cancer is the most common female death in women. Different studies are being done for treatment. The aim of this study was to investigate the antiproliferative, apoptotic and antioxidant effects of oleuropein and vitamin D both individually and in combination. Apoptosis is a programmed cell death pattern with genetic regulation that requires energy, allowing cells to be safely removed from the environment after performing their specified biological task. The olive tree has important biological properties and is rich in phenolic substances. These phenolic substances are mainly oleuropein. Oleuropein has many pharmacological effects such as antioxidant, antimicrobial, antiviral, anticancer, antiinflammatory, antiageing. Vitamin D is a hormone the kidneys produce that controls blood calcium concentration and impacts the immune system.

Keywords

• oleuropein
• vitaminD
• MCF-7
• cytotoxicity
• apoptosis
• antioxidant