Nature Communications (Jan 2019)
The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
- Xiaodong Zhuang,
- Andrea Magri,
- Michelle Hill,
- Alvina G. Lai,
- Abhinav Kumar,
- Srinivasa Bhargav Rambhatla,
- Claire L. Donald,
- Andrea F. Lopez-Clavijo,
- Simon Rudge,
- Katherine Pinnick,
- Wai Hoong Chang,
- Peter A. C. Wing,
- Ryan Brown,
- Ximing Qin,
- Peter Simmonds,
- Thomas F. Baumert,
- David Ray,
- Andrew Loudon,
- Peter Balfe,
- Michael Wakelam,
- Sam Butterworth,
- Alain Kohl,
- Catherine L. Jopling,
- Nicole Zitzmann,
- Jane A. McKeating
Affiliations
- Xiaodong Zhuang
- Nuffield Department of Medicine, University of Oxford
- Andrea Magri
- Nuffield Department of Medicine, University of Oxford
- Michelle Hill
- Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford
- Alvina G. Lai
- Nuffield Department of Medicine, University of Oxford
- Abhinav Kumar
- Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford
- Srinivasa Bhargav Rambhatla
- Institute of Immunology and Immunotherapy, University of Birmingham
- Claire L. Donald
- MRC-University of Glasgow Centre for Virus Research, University of Glasgow
- Andrea F. Lopez-Clavijo
- The Babraham Institute
- Simon Rudge
- The Babraham Institute
- Katherine Pinnick
- Oxford Centre for Diabetes Endocrinology Metabolism, University of Oxford
- Wai Hoong Chang
- Nuffield Department of Medicine, University of Oxford
- Peter A. C. Wing
- Nuffield Department of Medicine, University of Oxford
- Ryan Brown
- Department of Chemistry, University of Birmingham
- Ximing Qin
- Institutes of Physical Science and Information Technology, Anhui University
- Peter Simmonds
- Nuffield Department of Medicine, University of Oxford
- Thomas F. Baumert
- Inserm U1110, Institut de Recherche sur les Maladies Virales et Hépatiques
- David Ray
- Faculty of Medical and Human Sciences, University of Manchester
- Andrew Loudon
- Faculty of Medical and Human Sciences, University of Manchester
- Peter Balfe
- Institute of Immunology and Immunotherapy, University of Birmingham
- Michael Wakelam
- The Babraham Institute
- Sam Butterworth
- Division of Pharmacy and Optometry, School of Health Sciences, Manchester Academic Health Sciences Centre, University of Manchester
- Alain Kohl
- MRC-University of Glasgow Centre for Virus Research, University of Glasgow
- Catherine L. Jopling
- School of Pharmacy, University of Nottingham
- Nicole Zitzmann
- Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford
- Jane A. McKeating
- Nuffield Department of Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-019-08299-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The circadian clock can affect pathogen replication, but underlying molecular mechanisms are unclear. Here the authors demonstrate that the circadian components BMAL1 and REV-ERBα affect entry of hepatitis C virus (HCV) into hepatocytes and genome replication of HCV and related flaviviruses dengue and zika.
