Nature Communications (Mar 2020)

Quantification of the overall contribution of gene-environment interaction for obesity-related traits

  • Jonathan Sulc,
  • Ninon Mounier,
  • Felix Günther,
  • Thomas Winkler,
  • Andrew R. Wood,
  • Timothy M. Frayling,
  • Iris M. Heid,
  • Matthew R. Robinson,
  • Zoltán Kutalik

DOI
https://doi.org/10.1038/s41467-020-15107-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Most gene-by-environment interaction methods rely on the availability of the interacting environment. Here, the authors propose a robust maximum likelihood method for estimating the overall statistical interaction between a genetic risk score for a continuous outcome and all environmental variables.