Application of the Suzuki-Miyaura Reaction in the Synthesis of Flavonoids

Abstract

The application of the Suzuki-Miyaura reaction in the synthesis of flavonoids, an important class of natural products, is reviewed. This reaction has not only been employed to provide access to flavonoid nuclei, but has also been applied to the synthesis of dimeric flavonoids and in the synthesis of libraries of flavonoid derivatives for biological activity studies. The classes of flavonoids that are discussed are the chalcones, flavones, isoflavones, neoflavones, biflavones and derivatives of flavonoids obtained by C-C bond formation via the Suzuki-Miyaura reaction.

Keywords

• Suzuki-Miyaura reaction
• flavonoid
• chalcone
• flavone
• isoflavone
• neoflavone
• 4-arylcoumarin
• biflavone