A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

Chrysanthi Taxiarchi; Andrea Beaghton; Nayomi Illansinhage Don; Kyros Kyrou; Matthew Gribble; Dammy Shittu; Scott P. Collins; Chase L. Beisel; Roberto Galizi; Andrea Crisanti

doi:10.1038/s41467-021-24214-5

Nature Communications (Jun 2021)

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

Chrysanthi Taxiarchi,
Andrea Beaghton,
Nayomi Illansinhage Don,
Kyros Kyrou,
Matthew Gribble,
Dammy Shittu,
Scott P. Collins,
Chase L. Beisel,
Roberto Galizi,
Andrea Crisanti

Affiliations

Chrysanthi Taxiarchi: Department of Life Sciences, Imperial College London
Andrea Beaghton: Department of Life Sciences, Imperial College London
Nayomi Illansinhage Don: Department of Life Sciences, Imperial College London
Kyros Kyrou: Department of Life Sciences, Imperial College London
Matthew Gribble: Department of Life Sciences, Imperial College London
Dammy Shittu: Department of Life Sciences, Imperial College London
Scott P. Collins: Department of Chemical and Biomolecular Engineering, North Carolina State University
Chase L. Beisel: Department of Chemical and Biomolecular Engineering, North Carolina State University
Roberto Galizi: Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University
Andrea Crisanti: Department of Life Sciences, Imperial College London

DOI: https://doi.org/10.1038/s41467-021-24214-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 8

Abstract

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Technologies that can halt the spread of gene drives would be highly useful in controlling or reverting their effect. Here the authors use the anti-CRISPR protein AcrIIA4 to inactivate drives in A. gambiae.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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