PLoS ONE (Jan 2015)

Gout and Risk of Myocardial Infarction: A Systematic Review and Meta-Analysis of Cohort Studies.

  • Shuang-Chun Liu,
  • Lei Xia,
  • Jin Zhang,
  • Xue-Hong Lu,
  • Da-Kang Hu,
  • Hai-Tao Zhang,
  • Hai-Jun Li

DOI
https://doi.org/10.1371/journal.pone.0134088
Journal volume & issue
Vol. 10, no. 7
p. e0134088

Abstract

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IntroductionA high incidence of myocardial infarction among patients with gout has been suggested by several observational studies. We performed a meta-analysis to evaluate the association between gout and the risk of myocardial infarction.Materials and methodsThe PubMed and Embase databases were searched from inception to October 2014 for cohort studies that evaluating the association between gout and the risk of myocardial infarction. Summary estimates were derived using a random-effects model and reported as relative risks (RRs) with 95% confidence intervals (CIs).ResultsFive studies involving 8,656,413 participants with a total of 1000 MI events were included. Overall, gout was associated with an increased risk of myocardial infarction (RR 1.45; 95% CI, 1.19-1.75; pConclusionThis meta-analysis suggests that patients with gout have an increased risk of myocardial infarction.