Nature Communications (Feb 2016)

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

  • Tuomas O. Kilpeläinen,
  • Jayne F. Martin Carli,
  • Alicja A. Skowronski,
  • Qi Sun,
  • Jennifer Kriebel,
  • Mary F Feitosa,
  • Åsa K. Hedman,
  • Alexander W. Drong,
  • James E. Hayes,
  • Jinghua Zhao,
  • Tune H. Pers,
  • Ursula Schick,
  • Niels Grarup,
  • Zoltán Kutalik,
  • Stella Trompet,
  • Massimo Mangino,
  • Kati Kristiansson,
  • Marian Beekman,
  • Leo-Pekka Lyytikäinen,
  • Joel Eriksson,
  • Peter Henneman,
  • Jari Lahti,
  • Toshiko Tanaka,
  • Jian’an Luan,
  • Fabiola Del Greco M,
  • Dorota Pasko,
  • Frida Renström,
  • Sara M. Willems,
  • Anubha Mahajan,
  • Lynda M. Rose,
  • Xiuqing Guo,
  • Yongmei Liu,
  • Marcus E. Kleber,
  • Louis Pérusse,
  • Tom Gaunt,
  • Tarunveer S. Ahluwalia,
  • Yun Ju Sung,
  • Yolande F. Ramos,
  • Najaf Amin,
  • Antoinette Amuzu,
  • Inês Barroso,
  • Claire Bellis,
  • John Blangero,
  • Brendan M. Buckley,
  • Stefan Böhringer,
  • Yii-Der I Chen,
  • Anton J. N. de Craen,
  • David R. Crosslin,
  • Caroline E. Dale,
  • Zari Dastani,
  • Felix R. Day,
  • Joris Deelen,
  • Graciela E. Delgado,
  • Ayse Demirkan,
  • Francis M. Finucane,
  • Ian Ford,
  • Melissa E. Garcia,
  • Christian Gieger,
  • Stefan Gustafsson,
  • Göran Hallmans,
  • Susan E. Hankinson,
  • Aki S Havulinna,
  • Christian Herder,
  • Dena Hernandez,
  • Andrew A. Hicks,
  • David J. Hunter,
  • Thomas Illig,
  • Erik Ingelsson,
  • Andreea Ioan-Facsinay,
  • John-Olov Jansson,
  • Nancy S. Jenny,
  • Marit E. Jørgensen,
  • Torben Jørgensen,
  • Magnus Karlsson,
  • Wolfgang Koenig,
  • Peter Kraft,
  • Joanneke Kwekkeboom,
  • Tiina Laatikainen,
  • Karl-Heinz Ladwig,
  • Charles A. LeDuc,
  • Gordon Lowe,
  • Yingchang Lu,
  • Pedro Marques-Vidal,
  • Christa Meisinger,
  • Cristina Menni,
  • Andrew P. Morris,
  • Richard H. Myers,
  • Satu Männistö,
  • Mike A. Nalls,
  • Lavinia Paternoster,
  • Annette Peters,
  • Aruna D. Pradhan,
  • Tuomo Rankinen,
  • Laura J. Rasmussen-Torvik,
  • Wolfgang Rathmann,
  • Treva K. Rice,
  • J Brent Richards,
  • Paul M. Ridker,
  • Naveed Sattar,
  • David B. Savage,
  • Stefan Söderberg,
  • Nicholas J. Timpson,
  • Liesbeth Vandenput,
  • Diana van Heemst,
  • Hae-Won Uh,
  • Marie-Claude Vohl,
  • Mark Walker,
  • Heinz-Erich Wichmann,
  • Elisabeth Widén,
  • Andrew R. Wood,
  • Jie Yao,
  • Tanja Zeller,
  • Yiying Zhang,
  • Ingrid Meulenbelt,
  • Margreet Kloppenburg,
  • Arne Astrup,
  • Thorkild I. A. Sørensen,
  • Mark A. Sarzynski,
  • D. C. Rao,
  • Pekka Jousilahti,
  • Erkki Vartiainen,
  • Albert Hofman,
  • Fernando Rivadeneira,
  • André G. Uitterlinden,
  • Eero Kajantie,
  • Clive Osmond,
  • Aarno Palotie,
  • Johan G. Eriksson,
  • Markku Heliövaara,
  • Paul B. Knekt,
  • Seppo Koskinen,
  • Antti Jula,
  • Markus Perola,
  • Risto K. Huupponen,
  • Jorma S. Viikari,
  • Mika Kähönen,
  • Terho Lehtimäki,
  • Olli T. Raitakari,
  • Dan Mellström,
  • Mattias Lorentzon,
  • Juan P. Casas,
  • Stefanie Bandinelli,
  • Winfried März,
  • Aaron Isaacs,
  • Ko W. van Dijk,
  • Cornelia M. van Duijn,
  • Tamara B. Harris,
  • Claude Bouchard,
  • Matthew A. Allison,
  • Daniel I. Chasman,
  • Claes Ohlsson,
  • Lars Lind,
  • Robert A. Scott,
  • Claudia Langenberg,
  • Nicholas J. Wareham,
  • Luigi Ferrucci,
  • Timothy M. Frayling,
  • Peter P. Pramstaller,
  • Ingrid B. Borecki,
  • Dawn M. Waterworth,
  • Sven Bergmann,
  • Gérard Waeber,
  • Peter Vollenweider,
  • Henrik Vestergaard,
  • Torben Hansen,
  • Oluf Pedersen,
  • Frank B. Hu,
  • P Eline Slagboom,
  • Harald Grallert,
  • Tim D. Spector,
  • J.W. Jukema,
  • Robert J. Klein,
  • Erik E Schadt,
  • Paul W. Franks,
  • Cecilia M. Lindgren,
  • Rudolph L. Leibel,
  • Ruth J. F. Loos

DOI
https://doi.org/10.1038/ncomms10494
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

This meta-analysis of genome-wide association studies identifies four genetic loci associated with circulating leptin levels independent of adiposity. Examination in mouse adipose tissue explants provides functional support for the leptin-associated loci.