Nature Communications (Feb 2016)
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
- Tuomas O. Kilpeläinen,
- Jayne F. Martin Carli,
- Alicja A. Skowronski,
- Qi Sun,
- Jennifer Kriebel,
- Mary F Feitosa,
- Åsa K. Hedman,
- Alexander W. Drong,
- James E. Hayes,
- Jinghua Zhao,
- Tune H. Pers,
- Ursula Schick,
- Niels Grarup,
- Zoltán Kutalik,
- Stella Trompet,
- Massimo Mangino,
- Kati Kristiansson,
- Marian Beekman,
- Leo-Pekka Lyytikäinen,
- Joel Eriksson,
- Peter Henneman,
- Jari Lahti,
- Toshiko Tanaka,
- Jian’an Luan,
- Fabiola Del Greco M,
- Dorota Pasko,
- Frida Renström,
- Sara M. Willems,
- Anubha Mahajan,
- Lynda M. Rose,
- Xiuqing Guo,
- Yongmei Liu,
- Marcus E. Kleber,
- Louis Pérusse,
- Tom Gaunt,
- Tarunveer S. Ahluwalia,
- Yun Ju Sung,
- Yolande F. Ramos,
- Najaf Amin,
- Antoinette Amuzu,
- Inês Barroso,
- Claire Bellis,
- John Blangero,
- Brendan M. Buckley,
- Stefan Böhringer,
- Yii-Der I Chen,
- Anton J. N. de Craen,
- David R. Crosslin,
- Caroline E. Dale,
- Zari Dastani,
- Felix R. Day,
- Joris Deelen,
- Graciela E. Delgado,
- Ayse Demirkan,
- Francis M. Finucane,
- Ian Ford,
- Melissa E. Garcia,
- Christian Gieger,
- Stefan Gustafsson,
- Göran Hallmans,
- Susan E. Hankinson,
- Aki S Havulinna,
- Christian Herder,
- Dena Hernandez,
- Andrew A. Hicks,
- David J. Hunter,
- Thomas Illig,
- Erik Ingelsson,
- Andreea Ioan-Facsinay,
- John-Olov Jansson,
- Nancy S. Jenny,
- Marit E. Jørgensen,
- Torben Jørgensen,
- Magnus Karlsson,
- Wolfgang Koenig,
- Peter Kraft,
- Joanneke Kwekkeboom,
- Tiina Laatikainen,
- Karl-Heinz Ladwig,
- Charles A. LeDuc,
- Gordon Lowe,
- Yingchang Lu,
- Pedro Marques-Vidal,
- Christa Meisinger,
- Cristina Menni,
- Andrew P. Morris,
- Richard H. Myers,
- Satu Männistö,
- Mike A. Nalls,
- Lavinia Paternoster,
- Annette Peters,
- Aruna D. Pradhan,
- Tuomo Rankinen,
- Laura J. Rasmussen-Torvik,
- Wolfgang Rathmann,
- Treva K. Rice,
- J Brent Richards,
- Paul M. Ridker,
- Naveed Sattar,
- David B. Savage,
- Stefan Söderberg,
- Nicholas J. Timpson,
- Liesbeth Vandenput,
- Diana van Heemst,
- Hae-Won Uh,
- Marie-Claude Vohl,
- Mark Walker,
- Heinz-Erich Wichmann,
- Elisabeth Widén,
- Andrew R. Wood,
- Jie Yao,
- Tanja Zeller,
- Yiying Zhang,
- Ingrid Meulenbelt,
- Margreet Kloppenburg,
- Arne Astrup,
- Thorkild I. A. Sørensen,
- Mark A. Sarzynski,
- D. C. Rao,
- Pekka Jousilahti,
- Erkki Vartiainen,
- Albert Hofman,
- Fernando Rivadeneira,
- André G. Uitterlinden,
- Eero Kajantie,
- Clive Osmond,
- Aarno Palotie,
- Johan G. Eriksson,
- Markku Heliövaara,
- Paul B. Knekt,
- Seppo Koskinen,
- Antti Jula,
- Markus Perola,
- Risto K. Huupponen,
- Jorma S. Viikari,
- Mika Kähönen,
- Terho Lehtimäki,
- Olli T. Raitakari,
- Dan Mellström,
- Mattias Lorentzon,
- Juan P. Casas,
- Stefanie Bandinelli,
- Winfried März,
- Aaron Isaacs,
- Ko W. van Dijk,
- Cornelia M. van Duijn,
- Tamara B. Harris,
- Claude Bouchard,
- Matthew A. Allison,
- Daniel I. Chasman,
- Claes Ohlsson,
- Lars Lind,
- Robert A. Scott,
- Claudia Langenberg,
- Nicholas J. Wareham,
- Luigi Ferrucci,
- Timothy M. Frayling,
- Peter P. Pramstaller,
- Ingrid B. Borecki,
- Dawn M. Waterworth,
- Sven Bergmann,
- Gérard Waeber,
- Peter Vollenweider,
- Henrik Vestergaard,
- Torben Hansen,
- Oluf Pedersen,
- Frank B. Hu,
- P Eline Slagboom,
- Harald Grallert,
- Tim D. Spector,
- J.W. Jukema,
- Robert J. Klein,
- Erik E Schadt,
- Paul W. Franks,
- Cecilia M. Lindgren,
- Rudolph L. Leibel,
- Ruth J. F. Loos
Affiliations
- Tuomas O. Kilpeläinen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Jayne F. Martin Carli
- Department of Biochemistry and Molecular Biophysics, Columbia University
- Alicja A. Skowronski
- Institute of Human Nutrition, Columbia University
- Qi Sun
- Channing Division of Network Medicine, Department of Medicine Brigham and Women’s Hospital and Harvard Medical School
- Jennifer Kriebel
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
- Mary F Feitosa
- Department of Genetics, Washington University School of Medicine
- Åsa K. Hedman
- Science for Life Laboratory, Uppsala University
- Alexander W. Drong
- Wellcome Trust Centre for Human Genetics, University of Oxford
- James E. Hayes
- Cell and Developmental Biology Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University
- Jinghua Zhao
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge
- Tune H. Pers
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Ursula Schick
- Genetics of Obesity and Related Metabolic Traits Program, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Niels Grarup
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Zoltán Kutalik
- Institute of Social and Preventive Medicine, Lausanne University Hospital
- Stella Trompet
- Department of Cardiology, Leiden University Medical Center
- Massimo Mangino
- Department of Twin Research and Genetic Epidemiology King’s College London
- Kati Kristiansson
- Department of Health, National Institute for Health and Welfare
- Marian Beekman
- Department of Molecular Epidemiology, Leiden University Medical Center
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories
- Joel Eriksson
- Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy University of Gothenburg
- Peter Henneman
- Department of Human Genetics, Leiden University Medical Center
- Jari Lahti
- Institute of Behavioural Sciences, University of Helsinki
- Toshiko Tanaka
- Translational Gerontology Branch, National Institute on Aging
- Jian’an Luan
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge
- Fabiola Del Greco M
- Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) - Affiliated Institute of the University of Lübeck
- Dorota Pasko
- Genetics of Complex Traits, University of Exeter Medical School, University of Exeter
- Frida Renström
- Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University
- Sara M. Willems
- Department of Epidemiology, Erasmus MC
- Anubha Mahajan
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Lynda M. Rose
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Xiuqing Guo
- Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences
- Yongmei Liu
- Division of Public Health Sciences Wake Forest School of Medicine, Center for Human Genetics
- Marcus E. Kleber
- Vth Department of Medicine Heidelberg University, Medical Faculty Mannheim
- Louis Pérusse
- Department of Kinesiology, Laval University, Quebec City, Quebec, Canada G1V 0A6
- Tom Gaunt
- MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol
- Tarunveer S. Ahluwalia
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Yun Ju Sung
- Division of Biostatistics, Washington University School of Medicine
- Yolande F. Ramos
- Department of Molecular Epidemiology, Leiden University Medical Center
- Najaf Amin
- Department of Epidemiology, Genetic Epidemiology Unit, Erasmus MC
- Antoinette Amuzu
- Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine
- Inês Barroso
- Wellcome Trust Sanger Institute
- Claire Bellis
- Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore
- John Blangero
- Texas Biomedical Research Institute
- Brendan M. Buckley
- Department of Pharmacology and Therapeutics, University College Cork
- Stefan Böhringer
- Department of Molecular Epidemiology, Leiden University Medical Center
- Yii-Der I Chen
- Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences
- Anton J. N. de Craen
- Department of Gerontology and Geriatrics, Leiden University Medical Center
- David R. Crosslin
- Division of Medical Genetics, Department of Medicine University of Washington
- Caroline E. Dale
- Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine
- Zari Dastani
- Department of Human Genetics, McGill University
- Felix R. Day
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge
- Joris Deelen
- Department of Molecular Epidemiology, Leiden University Medical Center
- Graciela E. Delgado
- Vth Department of Medicine Heidelberg University, Medical Faculty Mannheim
- Ayse Demirkan
- Department of Human Genetics, Leiden University Medical Center
- Francis M. Finucane
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge
- Ian Ford
- Robertson Center for Biostatistics, University of Glasgow
- Melissa E. Garcia
- National Heart, Lung, and Blood Institute, NIH
- Christian Gieger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
- Stefan Gustafsson
- Science for Life Laboratory, Uppsala University
- Göran Hallmans
- Department of Biobank Research, Umeå University
- Susan E. Hankinson
- Channing Division of Network Medicine, Department of Medicine Brigham and Women’s Hospital and Harvard Medical School
- Aki S Havulinna
- Department of Health, National Institute for Health and Welfare
- Christian Herder
- German Center for Diabetes Research (DZD)
- Dena Hernandez
- Laboratory of Neurogenetics, National Institute on Aging
- Andrew A. Hicks
- Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) - Affiliated Institute of the University of Lübeck
- David J. Hunter
- Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health
- Thomas Illig
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
- Erik Ingelsson
- Science for Life Laboratory, Uppsala University
- Andreea Ioan-Facsinay
- Department of Rheumatology, Leiden University Medical Center
- John-Olov Jansson
- Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg
- Nancy S. Jenny
- Department of Pathology and Laboratory Medicine, Laboratory for Clinical Biochemistry Research, University of Vermont College of Medicine
- Marit E. Jørgensen
- Steno Diabetes Center
- Torben Jørgensen
- Research Centre for Prevention and Health, Glostrup University Hospital
- Magnus Karlsson
- Department of Clinical Sciences and Orthopaedic Surgery, Clinical and Molecular Osteoporosis Research Unit, Lund University, Skåne University Hospital
- Wolfgang Koenig
- Department of Internal Medicine II - Cardiology, University of Ulm
- Peter Kraft
- Department of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health
- Joanneke Kwekkeboom
- Department of Rheumatology, Leiden University Medical Center
- Tiina Laatikainen
- Department of Health, National Institute for Health and Welfare
- Karl-Heinz Ladwig
- Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health
- Charles A. LeDuc
- Division of Molecular Genetics, Department of Pediatrics Columbia University
- Gordon Lowe
- Institute of Cardiovascular and Medical Sciences, University of Glasgow
- Yingchang Lu
- Genetics of Obesity and Related Metabolic Traits Program, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Pedro Marques-Vidal
- Department of Internal Medicine, Lausanne University Hospital
- Christa Meisinger
- Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health
- Cristina Menni
- Department of Twin Research and Genetic Epidemiology King’s College London
- Andrew P. Morris
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Richard H. Myers
- Department of Neurology, Boston University School of Medicine
- Satu Männistö
- Department of Health, National Institute for Health and Welfare
- Mike A. Nalls
- Laboratory of Neurogenetics, National Institute on Aging
- Lavinia Paternoster
- MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol
- Annette Peters
- Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health
- Aruna D. Pradhan
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Tuomo Rankinen
- Human Genomics Laboratory, Pennington Biomedical Research Center
- Laura J. Rasmussen-Torvik
- Preventive Medicine, Northwestern Feinberg School of Medicine
- Wolfgang Rathmann
- Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf
- Treva K. Rice
- Division of Biostatistics, Washington University School of Medicine
- J Brent Richards
- Department of Twin Research and Genetic Epidemiology King’s College London
- Paul M. Ridker
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Naveed Sattar
- Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre
- David B. Savage
- The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science
- Stefan Söderberg
- Department of Public Health and Clinical Medicine, Cardiology and Heart Centre, Umeå University
- Nicholas J. Timpson
- MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol
- Liesbeth Vandenput
- Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy University of Gothenburg
- Diana van Heemst
- Department of Gerontology and Geriatrics, Leiden University Medical Center
- Hae-Won Uh
- Department of Molecular Epidemiology, Leiden University Medical Center
- Marie-Claude Vohl
- Institute of Nutrition and Functional Foods, Quebec City, Quebec, Canada G1V 0A6
- Mark Walker
- Institute of Cellular Medicine, Newcastle University
- Heinz-Erich Wichmann
- Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität and Klinikum Grosshadern
- Elisabeth Widén
- Institute for Molecular Medicine Finland, University of Helsinki
- Andrew R. Wood
- Genetics of Complex Traits, University of Exeter Medical School, University of Exeter
- Jie Yao
- Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences
- Tanja Zeller
- German Center for Cardiovascular Research (DZHK e.V.), partner site Hamburg/Kiel/Lübeck
- Yiying Zhang
- Division of Molecular Genetics, Department of Pediatrics Columbia University
- Ingrid Meulenbelt
- Department of Molecular Epidemiology, Leiden University Medical Center
- Margreet Kloppenburg
- Department of Rheumatology, Leiden University Medical Center
- Arne Astrup
- Department of Nutrition, Faculty of Science, Exercise, and Sports, University of Copenhagen, Copenhagen 1165, Denmark
- Thorkild I. A. Sørensen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Mark A. Sarzynski
- Human Genomics Laboratory, Pennington Biomedical Research Center
- D. C. Rao
- Department of Genetics, Washington University School of Medicine
- Pekka Jousilahti
- Department of Health, National Institute for Health and Welfare
- Erkki Vartiainen
- Department of Health, National Institute for Health and Welfare
- Albert Hofman
- Department of Epidemiology, Erasmus MC
- Fernando Rivadeneira
- Department of Epidemiology, Erasmus MC
- André G. Uitterlinden
- Department of Epidemiology, Erasmus MC
- Eero Kajantie
- Department of Health, National Institute for Health and Welfare
- Clive Osmond
- MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital
- Aarno Palotie
- Institute for Molecular Medicine Finland, University of Helsinki
- Johan G. Eriksson
- Department of Health, National Institute for Health and Welfare
- Markku Heliövaara
- Department of Health, National Institute for Health and Welfare
- Paul B. Knekt
- Department of Health, National Institute for Health and Welfare
- Seppo Koskinen
- Department of Health, National Institute for Health and Welfare
- Antti Jula
- Department of Health, National Institute for Health and Welfare
- Markus Perola
- Department of Health, National Institute for Health and Welfare
- Risto K. Huupponen
- Department of Pharmacology, Drug Development and Therapeutics University of Turku
- Jorma S. Viikari
- Division of Medicine, Turku University Hospital
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories
- Olli T. Raitakari
- Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital
- Dan Mellström
- Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy University of Gothenburg
- Mattias Lorentzon
- Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy University of Gothenburg
- Juan P. Casas
- Farr Institute of Health Informatics, University College London
- Stefanie Bandinelli
- Geriatric Unit, Azienda Sanitaria Firenze
- Winfried März
- Vth Department of Medicine Heidelberg University, Medical Faculty Mannheim
- Aaron Isaacs
- Department of Epidemiology, Genetic Epidemiology Unit, Erasmus MC
- Ko W. van Dijk
- Department of Human Genetics, Leiden University Medical Center
- Cornelia M. van Duijn
- Department of Epidemiology, Genetic Epidemiology Unit, Erasmus MC
- Tamara B. Harris
- Laboratory of Epidemiology and Population Science, National Institute on Aging
- Claude Bouchard
- Human Genomics Laboratory, Pennington Biomedical Research Center
- Matthew A. Allison
- Family and Preventive Medicine, University of California–San Diego
- Daniel I. Chasman
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Claes Ohlsson
- Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy University of Gothenburg
- Lars Lind
- Department of Medical Sciences, Cardiovascular Epidemiology Uppsala University
- Robert A. Scott
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge
- Claudia Langenberg
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge
- Nicholas J. Wareham
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge
- Luigi Ferrucci
- Translational Gerontology Branch, National Institute on Aging
- Timothy M. Frayling
- Genetics of Complex Traits, University of Exeter Medical School, University of Exeter
- Peter P. Pramstaller
- Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) - Affiliated Institute of the University of Lübeck
- Ingrid B. Borecki
- Department of Genetics, Washington University School of Medicine
- Dawn M. Waterworth
- GlaxoSmithKline
- Sven Bergmann
- Swiss Institute of Bioinformatics
- Gérard Waeber
- Department of Internal Medicine, Lausanne University Hospital
- Peter Vollenweider
- Department of Internal Medicine, Lausanne University Hospital
- Henrik Vestergaard
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Torben Hansen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Oluf Pedersen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Frank B. Hu
- Department of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health
- P Eline Slagboom
- Department of Molecular Epidemiology, Leiden University Medical Center
- Harald Grallert
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
- Tim D. Spector
- Department of Twin Research and Genetic Epidemiology King’s College London
- J.W. Jukema
- Department of Cardiology, Leiden University Medical Center
- Robert J. Klein
- Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Erik E Schadt
- Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Paul W. Franks
- Department of Nutrition, Harvard T.H. Chan School of Public Health
- Cecilia M. Lindgren
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Rudolph L. Leibel
- Division of Molecular Genetics, Department of Pediatrics Columbia University
- Ruth J. F. Loos
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge
- DOI
- https://doi.org/10.1038/ncomms10494
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
This meta-analysis of genome-wide association studies identifies four genetic loci associated with circulating leptin levels independent of adiposity. Examination in mouse adipose tissue explants provides functional support for the leptin-associated loci.