Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation

Christopher M. Bobba; Qinqin Fei; Vasudha Shukla; Hyunwook Lee; Pragi Patel; Rachel K. Putman; Carleen Spitzer; MuChun Tsai; Mark D. Wewers; Robert J. Lee; John W. Christman; Megan N. Ballinger; Samir N. Ghadiali; Joshua A. Englert

doi:10.1038/s41467-020-20449-w

Nature Communications (Jan 2021)

Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation

Christopher M. Bobba,
Qinqin Fei,
Vasudha Shukla,
Hyunwook Lee,
Pragi Patel,
Rachel K. Putman,
Carleen Spitzer,
MuChun Tsai,
Mark D. Wewers,
Robert J. Lee,
John W. Christman,
Megan N. Ballinger,
Samir N. Ghadiali,
Joshua A. Englert

Affiliations

Christopher M. Bobba: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center
Qinqin Fei: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center
Vasudha Shukla: Department of Biomedical Engineering, The Ohio State University
Hyunwook Lee: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center
Pragi Patel: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center
Rachel K. Putman: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women’s Hospital
Carleen Spitzer: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center
MuChun Tsai: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center
Mark D. Wewers: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center
Robert J. Lee: Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University
John W. Christman: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center
Megan N. Ballinger: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center
Samir N. Ghadiali: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center
Joshua A. Englert: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center

DOI: https://doi.org/10.1038/s41467-020-20449-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

There are no targeted pharmacologic therapies to treat lung injury during mechanical ventilation (MV). Here the authors identify a mechanosensitive microRNA (miR-146a) in alveolar macrophages during MV and increase miR-146a to supraphysiological levels in these cells to mitigate ventilator induced lung injury.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal