Veterinary Sciences (Nov 2022)
The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models
- Silvia A. Teixeira,
- Mayara de Cassia Luzzi,
- Ana Carolina Baptista Moreno Martin,
- Terence Teixeira Duarte,
- Mônica de Oliveira Leal,
- Gustavo Ramos Teixeira,
- Monise Tadin Reis,
- Carlos Roberto Almeida Junior,
- Karina Santos,
- Matias Eliseo Melendez,
- Diego da Cunha Silveira Alves da Silva,
- Priscila Neves Bernécule,
- Higor Vinicius Lourenço Firmino,
- Ana Laura Vieira Alves,
- Denise Peixoto Guimarães,
- João Vitor Borduqui,
- Ana Carolina Laus,
- Bruna Minniti Mançano,
- Rui Manuel Reis
Affiliations
- Silvia A. Teixeira
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Mayara de Cassia Luzzi
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Ana Carolina Baptista Moreno Martin
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Terence Teixeira Duarte
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Mônica de Oliveira Leal
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Gustavo Ramos Teixeira
- Department of Pathology, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Monise Tadin Reis
- Department of Pathology, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Carlos Roberto Almeida Junior
- Department of Neurosurgery, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Karina Santos
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Matias Eliseo Melendez
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Diego da Cunha Silveira Alves da Silva
- Department of Radiology, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Priscila Neves Bernécule
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Higor Vinicius Lourenço Firmino
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Ana Laura Vieira Alves
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Denise Peixoto Guimarães
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- João Vitor Borduqui
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Ana Carolina Laus
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Bruna Minniti Mançano
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- Rui Manuel Reis
- Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, São Paulo, Brazil
- DOI
- https://doi.org/10.3390/vetsci9110636
- Journal volume & issue
-
Vol. 9,
no. 11
p. 636
Abstract
The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and ApcMin mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.
Keywords
- PTCH1-knockout
- <i>Apc<sup>Min</sup></i>
- xenografts
- PDX
- genetically engineered mouse models
- personalized therapy
