Nature Communications (Aug 2020)

Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF

  • Hongri Gong,
  • Yan Gao,
  • Xiaoting Zhou,
  • Yu Xiao,
  • Weiwei Wang,
  • Yanting Tang,
  • Shan Zhou,
  • Yuying Zhang,
  • Wenxin Ji,
  • Lu Yu,
  • Changlin Tian,
  • Sin Man Lam,
  • Guanghou Shui,
  • Luke W. Guddat,
  • Luet-Lok Wong,
  • Quan Wang,
  • Zihe Rao

DOI
https://doi.org/10.1038/s41467-020-18011-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

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Diheme-containing succinate:menaquinone oxidoreductases (Sdh) are members of the complex II superfamily. Here, the authors present the 2.8 Å cryo-EM structure of Mycobacterium smegmatis Sdh2, which reveals membrane-anchored SdhF as a component of the complex and they discuss the electron/proton transfer pathway in the Sdh2 trimer.