Data on in vivo antioxidant, hypolipidemic and hepatoprotective potential of Thaumatococcus daniellii (Benn.) Benth leaves
Shalom Nwodo Chinedu,
Franklyn Nonso Iheagwam,
Boluwatife Taiwo Makinde,
Babajide Oladipo Thorpe,
Opeyemi Christianah Emiloju
Affiliations
Shalom Nwodo Chinedu
Department of Biochemistry, College of Science and Technology, Covenant University, P.M.B. 1023, Canaanland, Ota, Ogun State, Nigeria; Covenant University Public Health and Wellness Research Cluster (CUPHWERC), Covenant University, P.M.B. 1023, Canaanland, Ota, Ogun State, Nigeria; Corresponding authors.
Franklyn Nonso Iheagwam
Department of Biochemistry, College of Science and Technology, Covenant University, P.M.B. 1023, Canaanland, Ota, Ogun State, Nigeria; Covenant University Public Health and Wellness Research Cluster (CUPHWERC), Covenant University, P.M.B. 1023, Canaanland, Ota, Ogun State, Nigeria; Corresponding authors.
Boluwatife Taiwo Makinde
Department of Biochemistry, College of Science and Technology, Covenant University, P.M.B. 1023, Canaanland, Ota, Ogun State, Nigeria
Babajide Oladipo Thorpe
Department of Biochemistry, College of Science and Technology, Covenant University, P.M.B. 1023, Canaanland, Ota, Ogun State, Nigeria
Opeyemi Christianah Emiloju
Department of Biochemistry, College of Science and Technology, Covenant University, P.M.B. 1023, Canaanland, Ota, Ogun State, Nigeria; Covenant University Public Health and Wellness Research Cluster (CUPHWERC), Covenant University, P.M.B. 1023, Canaanland, Ota, Ogun State, Nigeria
This data article reports on the in vivo biochemical activity of ethanolic extract of Thaumatococcus daniellii (Benn.) Benth leaves (ETD) in male Wistar rats at an oral dose of 500–1500 mg/kg daily for 14 days. Control groups were administered distilled water and Vitamin C (10 mg/kg; b.wt). Indices of oxidative stress, dyslipidemia, liver injury and liver pathology were estimated in the plasma and organs after the investigation period. Oral treatment with ETD increased organ superoxide dismutase (SOD) activity, renal reduced glutathione (GSH) and plasma high density lipoprotein (HDL) concentrations while reducing plasma alanine transaminase (ALT) activity, plasma cholesterol (CHOL), bilirubin (DBIL) and organ malondialdehyde (MDA) concentrations (P<0.05). Data was supported by histological report showing no pathologic abnormality. This data indicate ethanolic extract of T. daniellii leaves shows antioxidant, hypolipidemic and hepatoprotective potential. Keywords: Thaumatococcus daniellii, in vivo, Oxidative stress, Antioxidant, Liver injury, Hypolipidemic
