Frontiers in Immunology (Dec 2021)

miR-223: An Immune Regulator in Infectious Disorders

  • Shun Yuan,
  • Qi Wu,
  • Zhiwei Wang,
  • Yanjia Che,
  • Sihao Zheng,
  • Yuanyang Chen,
  • Xiaohan Zhong,
  • Feng Shi

DOI
https://doi.org/10.3389/fimmu.2021.781815
Journal volume & issue
Vol. 12

Abstract

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MicroRNAs (miRNAs) are diminutive noncoding RNAs that can influence disease development and progression by post-transcriptionally regulating gene expression. The anti-inflammatory miRNA, miR-223, was first identified as a regulator of myelopoietic differentiation in 2003. This miR-223 exhibits multiple regulatory functions in the immune response, and abnormal expression of miR-223 is shown to be associated with multiple infectious diseases, including viral hepatitis, human immunodeficiency virus type 1 (HIV-1), and tuberculosis (TB) by influencing neutrophil infiltration, macrophage function, dendritic cell (DC) maturation and inflammasome activation. This review summarizes the current understanding of miR-223 physiopathology and highlights the molecular mechanism by which miR-223 regulates immune responses to infectious diseases and how it may be targeted for diagnosis and treatment.

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