Frontiers in Pharmacology (Apr 2020)

Silver Nanoparticles Coated Poly(L-Lactide) Electrospun Membrane for Implant Associated Infections Prevention

  • Jiaolong Wang,
  • Jiaolong Wang,
  • Lilin Zhan,
  • Lilin Zhan,
  • Xianhua Zhang,
  • Xianhua Zhang,
  • Runfa Wu,
  • Runfa Wu,
  • Lan Liao,
  • Lan Liao,
  • Junchao Wei,
  • Junchao Wei,
  • Junchao Wei

DOI
https://doi.org/10.3389/fphar.2020.00431
Journal volume & issue
Vol. 11

Abstract

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Bacterial infection has been a critic problem for implant infections. Poly(L-lactide) (PLLA) membrane has great potential for Guided bone regeneration (GBR), however, PLLA lack antibacterial property and thus may face bacterial infections. In this work, a mussel inspired method was used to treat PLLA membrane with dopamine and formed polydopamine (PDA) coated PLLA (PLLA@PDA), and then silver Nanoparticles (AgNPs) was immobilized on the surface of PLLA via the reduction effect of PDA. The XPS results showed that the silver element contents may be tuned from 1.6% to 15.4%. The AgNPs coated PLLA (PLLA@Ag) showed good antibacterial property (98.3% bactericidal efficiency may be obtained) and good biocompatibility, implying that the PLLA@Ag membrane have potential application as antibacterial GBR membrane, which may enhance the application of PLLA.

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