P53 regulates cellular redox state, ferroptosis and metabolism

Abstract

The tumor protein P53 (TP53, or p53) has complex and at times seemingly contradictory roles in the regulation of metabolism and ferroptosis sensitivity. We find that the actions of p53 influence the redox state, which can trigger changes in redox-sensitive proteins, thereby modifying metabolic processes and response to ferroptosis.

Keywords

• ferroptosis
• p53
• metabolism
• cysteine modification
• redox signaling