Research progress on the relationship between lung microbiome and lung cancer

Abstract

Lung cancer is the leading cause of cancer-related deaths worldwide. Lung microbiome is defined as the microbial organisms located in the lung. With rapid development of next-generation sequencing， microbiome has been found to affect the host’s nutrition， immunity， metabolism and the occurrence or development of diseases including cancer. Dysbiosis of lung microbiome causes persistent airway inflammation and immune disorders， which affects the occurrence and development of lung cancer. In-depth exploration of lung microecological characteristics of lung cancer patients can be applied to early diagnosis， treatment and prognosis of lung cancer， which is beneficial to improve clinical efficacy of lung cancer. In this article， research progress on lung microbiome in lung cancer was reviewed.

Keywords

• lung microbiome|lung cancer|microorganism|immunotherapy|biomarker