Study of neuropsychotropic properties of substance with neuroprotective activity dimeric dipeptide mimethic of human NGF, GK-2h

Abstract

Dimeric dipeptide mimethic human nerve growth factor, bis-(N-monosucciniL-gLycyL-Lysine), GK-2h at doses 0,1, 0,5, 1,0, 1,5 mg/kg, i.p. has an antiamnesic effect on the modeLs of scopoLamine, maximaL eLectroshock or ketamin induced passive avoidance response amnesia. GK-2h at doses 1,0-1,5 mg/ kg possess weak antihypoxic und anticonvuLsive properties, it does not affect the expLoratory behavior of animaLs in the test of open fieLd.

Keywords

• димерный дипептидный миметик фактора роста нервов человека
• антиамнестический и противогипоксиче-ский эффекты
• mimetic human ngf bis-(n-monosuccinil-glycyl-lysine)
• gk-2h
• antiamnestic
• antihypoxic effects