Centromere evolution and CpG methylation during vertebrate speciation

Kazuki Ichikawa; Shingo Tomioka; Yuta Suzuki; Ryohei Nakamura; Koichiro Doi; Jun Yoshimura; Masahiko Kumagai; Yusuke Inoue; Yui Uchida; Naoki Irie; Hiroyuki Takeda; Shinich Morishita

doi:10.1038/s41467-017-01982-7

Nature Communications (Nov 2017)

Centromere evolution and CpG methylation during vertebrate speciation

Kazuki Ichikawa,
Shingo Tomioka,
Yuta Suzuki,
Ryohei Nakamura,
Koichiro Doi,
Jun Yoshimura,
Masahiko Kumagai,
Yusuke Inoue,
Yui Uchida,
Naoki Irie,
Hiroyuki Takeda,
Shinich Morishita

Affiliations

Kazuki Ichikawa: Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa
Shingo Tomioka: Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa
Yuta Suzuki: Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa
Ryohei Nakamura: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku
Koichiro Doi: Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa
Jun Yoshimura: Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa
Masahiko Kumagai: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku
Yusuke Inoue: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku
Yui Uchida: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku
Naoki Irie: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku
Hiroyuki Takeda: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku
Shinich Morishita: Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa

DOI: https://doi.org/10.1038/s41467-017-01982-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Centromeres and large-scale structural variants evolve and contribute to genome diversity during vertebrate speciation. Here Ichikawa et al perform de novo long-read genome assembly of three inbred medaka strains, and report long-range structure of centromeres and their methylation as well as correlation of structural variants with differential gene expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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