Frontiers in Cell and Developmental Biology (Mar 2022)
Defects of Nutrient Signaling and Autophagy in Neurodegeneration
- Jon Ondaro,
- Jon Ondaro,
- Haizea Hernandez-Eguiazu,
- Haizea Hernandez-Eguiazu,
- Maddi Garciandia-Arcelus,
- Maddi Garciandia-Arcelus,
- Raúl Loera-Valencia,
- Laura Rodriguez-Gómez,
- Laura Rodriguez-Gómez,
- Andrés Jiménez-Zúñiga,
- Andrés Jiménez-Zúñiga,
- Julen Goikolea,
- Patricia Rodriguez-Rodriguez,
- Javier Ruiz-Martinez,
- Javier Ruiz-Martinez,
- Javier Ruiz-Martinez,
- Fermín Moreno,
- Fermín Moreno,
- Fermín Moreno,
- Adolfo Lopez de Munain,
- Adolfo Lopez de Munain,
- Adolfo Lopez de Munain,
- Ian James Holt,
- Ian James Holt,
- Ian James Holt,
- Ian James Holt,
- Francisco Javier Gil-Bea,
- Francisco Javier Gil-Bea,
- Gorka Gereñu,
- Gorka Gereñu,
- Gorka Gereñu
Affiliations
- Jon Ondaro
- Department of Neuroscience, Biodonostia Health Research Institute (IIS Biodonostia), San Sebastian, Spain
- Jon Ondaro
- Center for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Madrid, Spain
- Haizea Hernandez-Eguiazu
- Department of Neuroscience, Biodonostia Health Research Institute (IIS Biodonostia), San Sebastian, Spain
- Haizea Hernandez-Eguiazu
- Center for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Madrid, Spain
- Maddi Garciandia-Arcelus
- Department of Neuroscience, Biodonostia Health Research Institute (IIS Biodonostia), San Sebastian, Spain
- Maddi Garciandia-Arcelus
- Center for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Madrid, Spain
- Raúl Loera-Valencia
- Department of Neurology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet (KI), Stockholm, Sweden
- Laura Rodriguez-Gómez
- Department of Neuroscience, Biodonostia Health Research Institute (IIS Biodonostia), San Sebastian, Spain
- Laura Rodriguez-Gómez
- Center for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Madrid, Spain
- Andrés Jiménez-Zúñiga
- Department of Neuroscience, Biodonostia Health Research Institute (IIS Biodonostia), San Sebastian, Spain
- Andrés Jiménez-Zúñiga
- Center for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Madrid, Spain
- Julen Goikolea
- Department of Neurology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet (KI), Stockholm, Sweden
- Patricia Rodriguez-Rodriguez
- Department of Neurology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet (KI), Stockholm, Sweden
- Javier Ruiz-Martinez
- Department of Neuroscience, Biodonostia Health Research Institute (IIS Biodonostia), San Sebastian, Spain
- Javier Ruiz-Martinez
- Center for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Madrid, Spain
- Javier Ruiz-Martinez
- Donostia University Hospital, San Sebastian, Spain
- Fermín Moreno
- Department of Neuroscience, Biodonostia Health Research Institute (IIS Biodonostia), San Sebastian, Spain
- Fermín Moreno
- Center for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Madrid, Spain
- Fermín Moreno
- Donostia University Hospital, San Sebastian, Spain
- Adolfo Lopez de Munain
- Department of Neuroscience, Biodonostia Health Research Institute (IIS Biodonostia), San Sebastian, Spain
- Adolfo Lopez de Munain
- Center for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Madrid, Spain
- Adolfo Lopez de Munain
- Donostia University Hospital, San Sebastian, Spain
- Ian James Holt
- Department of Neuroscience, Biodonostia Health Research Institute (IIS Biodonostia), San Sebastian, Spain
- Ian James Holt
- Center for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Madrid, Spain
- Ian James Holt
- Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom
- Ian James Holt
- IKERBASQUE Basque Foundation for Science, Bilbao, Spain
- Francisco Javier Gil-Bea
- Department of Neuroscience, Biodonostia Health Research Institute (IIS Biodonostia), San Sebastian, Spain
- Francisco Javier Gil-Bea
- Center for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Madrid, Spain
- Gorka Gereñu
- Department of Neuroscience, Biodonostia Health Research Institute (IIS Biodonostia), San Sebastian, Spain
- Gorka Gereñu
- Center for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Madrid, Spain
- Gorka Gereñu
- Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country (UPV-EHU), Leioa, Spain
- DOI
- https://doi.org/10.3389/fcell.2022.836196
- Journal volume & issue
-
Vol. 10
Abstract
Neurons are post-mitotic cells that allocate huge amounts of energy to the synthesis of new organelles and molecules, neurotransmission and to the maintenance of redox homeostasis. In neurons, autophagy is not only crucial to ensure organelle renewal but it is also essential to balance nutritional needs through the mobilization of internal energy stores. A delicate crosstalk between the pathways that sense nutritional status of the cell and the autophagic processes to recycle organelles and macronutrients is fundamental to guarantee the proper functioning of the neuron in times of energy scarcity. This review provides a detailed overview of the pathways and processes involved in the balance of cellular energy mediated by autophagy, which when defective, precipitate the neurodegenerative cascade of Parkinson’s disease, frontotemporal dementia, amyotrophic lateral sclerosis or Alzheimer’s disease.
Keywords
- neurodegenerative diseases
- autophagy
- nutrient sensing pathways
- mitochondrial metabolism
- lipid metabolism
- glucose metabolism
