Фундаментальная и клиническая медицина (Mar 2016)
RISK FACTORS OF TREATMENT FAILURE AND RECURRENT ENDOMETRIAL HYPERPLASIA IN WOMEN OF REPRODUCTIVE AGE WITH OBESITY
Abstract
Aim: To identify the risk factors for treatment failure and recurrent endometrial hyperplasia in women of reproductive age with obesity. Materials and Methods: We performed a retrospective, case-control study. The study included 92 women of reproductive age with obesity and simple endometrial hyperplasia without atypia. All patients received norethisterone therapy at a dose of 10 mg per day, 16-25 day cycle for 6 months, followed by endometrial biopsy and histological examination. Group I consisted of 36 patients with relapsing endometrial hyperplasia while group II included 56 patients without relapse. Results: Stepwise discriminant analysis of 162 parameters revealed 11 significant factors associated with endometrial hyperplasia in women of reproductive age with obesity. Severe obesity, android fat distribution, duration of obesity and infertility, metabolic (hyperglycemia, hypertriglyceridemia, reduced high density lipoprotein cholesterol) and hormonal disorders (hyperestradiolemia, hypertestosteronemia, hyperleptinemia) were the most significant predictors of treatment failure and/or recurrent endometrial hyperplasia in women of reproductive age with obesity. Conclusions: Features of the metabolic and hormonal profile in women of reproductive age with obesity should be taken into account in treatment of endometrial hyperplasia.
