Quorum-quenching activity of some Iranian medicinal plants

Abstract

Anti-quorum sensing (QS) or quorum quenching (QQ) is known as a new anti-bacterial strategy to combat bacterial infection. One of the best candidates for this strategy is a natural plant or traditional herbal medicine. This review aimed to summarize and introduce Iranian medicinal plants with anti-QS properties. Biomedical databases (PubMed, Scopus, Google Scholar and Web of sciences) were investigated to retrieve all related manuscripts published in English and Persian. Out of 65 documents, 47 papers were published during 2010–2020. We categorized and summarized 19 papers that particularly presented the anti-QS activity of Iranian medicinal plants. Based on our results, different studies have been completed on the QQ effects of medicinal plants. We identified 106 plant species with different properties in medicine that have been evaluated for anti-QS activities in Iran. The QQ effects of herbal extracts were identified through different in vitro examinations on biosensor and clinical bacterial strains. Only 35 medicinal plants have shown these effects at sub-MICs. Our review summarizes Iranian medicinal plants with anti-QS properties. Some of these herbal extracts showed anti-QS activity against biosensors, standard and clinical bacterial strains. This result is very important because QS systems can be considered as a new target for the development of new remedial strategies and it is a good opportunity to perform QQ studies to effectively combat bacterial infections in the future.

Keywords

• Anti-quorum sensing
• bacterial signaling
• in-vitro assays
• Iran
• medicinal plants
• new remedial