ABCD: Arquivos Brasileiros de Cirurgia Digestiva (Jan 2019)

THE CANONICAL WNT PATHWAY IN GASTRIC CARCINOMA

  • Levindo Alves de OLIVEIRA,
  • Celina Tizuko Fujiyama OSHIMA,
  • Pedro Augusto SOFFNER,
  • Marcelo de Souza SILVA,
  • Rodrigo Rego LINS,
  • Andréa Cristina de Moraes MALINVERNI,
  • Jaques WAISBERG

DOI
https://doi.org/10.1590/0102-672020180001e1414
Journal volume & issue
Vol. 32, no. 1

Abstract

Read online Read online

ABSTRACT Background : It is believed that the Wnt pathway is one of the most important signaling involved in gastric carcinogenesis. Aim : To analyze the protein expression of canonical and non-canonical Wnt pathways in gastric carcinoma. Method : The immunohistochemistry was performed in 72 specimens of gastric carcinomas for evaluating the expression of Wnt-5a, FZD5, GSK3β, axin, CK1, ubiquitin, cyclin D1 and c-myc. Results : There were significant differences for cytoplasm and nucleus ubiquitin for moderately and well differentiated tumors (p=0.03) and for those of the intestinal type of the Lauren classification (p=0.03). The absence of c-myc was related to Lauren’s intestinal tumors (p=0.03). Expression of CK1 in the cytoplasm was related to compromised margin (p=0.03). Expression of cyclin D1 protein was more intense in male patients (p=0.03) There was no relation of the positive or negative expression of the Wnt-5a, FZD5, GSK3 and Axin with any clinicopathological variables. Conclusion: The canonical WNT pathway is involved in gastric carcinoma.

Keywords