Frontiers in Cellular and Infection Microbiology (Nov 2024)
Potential protective role of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in COVID-19
- Mateus V. de Castro,
- Leonardo M. Cariste,
- Leonardo M. Cariste,
- Leonardo M. Cariste,
- Rafael R. Almeida,
- Rafael R. Almeida,
- Rafael R. Almeida,
- Greyce L. Sasahara,
- Greyce L. Sasahara,
- Greyce L. Sasahara,
- Monize V. R. Silva,
- Flávia B. Soares,
- Vivian R. Coria,
- Michel S. Naslavsky,
- Keity S. Santos,
- Keity S. Santos,
- Keity S. Santos,
- Edecio Cunha-Neto,
- Edecio Cunha-Neto,
- Edecio Cunha-Neto,
- Jorge Kalil,
- Jorge Kalil,
- Jorge Kalil,
- Mayana Zatz
Affiliations
- Mateus V. de Castro
- Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
- Leonardo M. Cariste
- Laboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil
- Leonardo M. Cariste
- Instutute on Investigation in Immunology, - Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil
- Leonardo M. Cariste
- Division of Clinical Immunology and Allergy, Departamento de Clínica Médica, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
- Rafael R. Almeida
- Laboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil
- Rafael R. Almeida
- Instutute on Investigation in Immunology, - Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil
- Rafael R. Almeida
- Division of Clinical Immunology and Allergy, Departamento de Clínica Médica, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
- Greyce L. Sasahara
- Laboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil
- Greyce L. Sasahara
- Instutute on Investigation in Immunology, - Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil
- Greyce L. Sasahara
- Division of Clinical Immunology and Allergy, Departamento de Clínica Médica, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
- Monize V. R. Silva
- Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
- Flávia B. Soares
- Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
- Vivian R. Coria
- Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
- Michel S. Naslavsky
- Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
- Keity S. Santos
- Laboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil
- Keity S. Santos
- Instutute on Investigation in Immunology, - Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil
- Keity S. Santos
- Division of Clinical Immunology and Allergy, Departamento de Clínica Médica, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
- Edecio Cunha-Neto
- Laboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil
- Edecio Cunha-Neto
- Instutute on Investigation in Immunology, - Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil
- Edecio Cunha-Neto
- Division of Clinical Immunology and Allergy, Departamento de Clínica Médica, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
- Jorge Kalil
- Laboratory of Immunology, Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, (HCFMUSP), São Paulo, Brazil
- Jorge Kalil
- Instutute on Investigation in Immunology, - Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo, Brazil
- Jorge Kalil
- Division of Clinical Immunology and Allergy, Departamento de Clínica Médica, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
- Mayana Zatz
- Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
- DOI
- https://doi.org/10.3389/fcimb.2024.1464581
- Journal volume & issue
-
Vol. 14
Abstract
The COVID-19 pandemic has prompted a quest to understand why certain individuals remain uninfected or asymptomatic despite repetitive exposure to SARS-CoV-2. Here, we focused on six exposed females residing with their symptomatic and reinfected SARS-CoV-2 PCR-positive COVID-19 partners. Peripheral blood mononuclear cell samples from couples were analysed for poly (I:C)-induced mRNA expression of type I/III interferons and interferon-stimulated genes (ISGs). Remarkably, we found a significant upregulation of the ISG interferon-inducible protein with tetrapeptide repeats 3 (IFIT3) gene exclusively in exposed uninfected or asymptomatic females, suggesting a potential role in protective immunity against symptomatic COVID-19.
Keywords
