Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B

Abstract

The natural dipeptide antibiotic TAN 1057 A,B represents a promising new antibiotic entity. In this communication we report a novel approach for the synthesis of TAN 1057 A,B analogs bearing variations in the β-arginine side chain. This approach involves a combination of liquid and solid phase methods and allows for a library synthesis of analogs of the natural product.

Keywords

• TAN 1057 A
• B
• dipeptide antibiotics
• combinatorial chemistry