Química Nova (Jan 2013)

Síntese, caracterização e estudo das propriedades de um novo complexo mononuclear contendo quercetina e íon Ga(III) Synthesis, characterization and study of the properties of a new mononuclear quercetin complex containing Ga(III) ions

  • Vanessa do Nascimento Simões,
  • Lis Regiane Vizolli Favarin,
  • Natália Aparecida Cabeza,
  • Tamires Donizeth de Oliveira,
  • Antonio Rogério Fiorucci,
  • Jusinei Meireles Stropa,
  • Daniela Cristina Manfroi Rodrigues,
  • Alberto Adriano Cavalheiro,
  • Ademir dos Anjos

Journal volume & issue
Vol. 36, no. 4
pp. 495 – 501

Abstract

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Flavonoids are one of the most important compound groups applied as medicine given their antioxidant properties, but several intrinsic properties can be improved through structural modifications to their molecules. Here, the synthesis and characterization of a new gallium (III) complex with quercetin is described. Electrochemical properties, as well as antioxidant and cytotoxic activities, were investigated and compared to the free flavonoid molecule. The mononuclear complex obtained, [Ga(C15H9O7)3].2H2O.2CH3OH.CH3CH2OH, seems more active as a DPPH radical scavenger given its lower oxidation potential compared to quercetin. The new complex cytotoxic responses have shown to be more effective than those of the free flavonoid and of lapachol used as a control.

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