Research progress on the mechanism of angiocrine factors regulating lung regeneration and fibrosis

Abstract

Mammalian lungs have a certain ability to repair and regenerate following injury, which ability could decline with age and persistent damage, leading to fibrosis. Pulmonary fibrosis represents a major cause of death worldwide with limited therapeutic options. Endothelial cells balance the regeneration and fibrosis of damaged lung by orchestrating the diverse angiocrine factors. More knowledge about the active regulation of angiocrine factors has provide future treatment options for lung diseases. In this review, we mainly summarize the latest research progress on the regulatory mechanisms of vascular niche in lung regeneration and fibrosis. In addition, we also summarize various in / ex vivo models for studying lung disease, and discuss the potential of targeted editing of vascular niche to promote lung regeneration.

Keywords

• vascular endothelial cell
• angiocrine factors
• vascular niche
• lung regeneration
• lung fibrosis