Analysis of Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA) Parameters in Young Adults after SARS-CoV-2 Infection (COVID-19) Compared with Healthy Young Controls
Anahita Bajka,
Daniel Rudolf Muth,
Maximilian Robert Justus Wiest,
Sadiq Said,
Magdalena Rejdak,
Sophia Sidhu,
Nastasia Foa,
Frank Blaser,
Daniel Barthelmes,
Mario Damiano Toro,
Eric H. Souied,
Jeremy Werner Deuel,
Patricia Schlagenhauf,
Sandrine Anne Zweifel
Affiliations
Anahita Bajka
Department of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland
Daniel Rudolf Muth
Department of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland
Maximilian Robert Justus Wiest
Department of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland
Sadiq Said
Department of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland
Magdalena Rejdak
Department of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland
Sophia Sidhu
Faculty of Medicine, University of California, San Diego, CA 92093, USA
Nastasia Foa
Department of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland
Frank Blaser
Department of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland
Daniel Barthelmes
Department of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland
Mario Damiano Toro
Department of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland
Eric H. Souied
Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris Est Creteil, 94000 Creteil, France
Jeremy Werner Deuel
Department of Global and Public Health, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, 8001 Zurich, Switzerland
Patricia Schlagenhauf
Department of Global and Public Health, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, 8001 Zurich, Switzerland
Sandrine Anne Zweifel
Department of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland
Purpose: To compare retinal changes in young adults with previous SARS-CoV-2 infection with healthy young controls using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Methods: This prospective single-center study was conducted at the University Hospital of Zurich, Zurich, Switzerland. Participants were imaged from May to November 2021 using the SOLIX device (Visionix International SAS, Pont-de-l’Arche, France). We performed 12 mm × 12 mm, 6.4 mm × 6.4 mm, 6 mm × 6 mm and 3 mm × 3 mm OCT and OCTA scans, as well as fundus photography of each participant’s eyes. Results: In total, 466 participants were imaged. Of these, 233 were healthy controls with negative RT-PCR tests for SARS-CoV-2, 168 were young adults who had a SARS-CoV-2 infection at least 180 days previously, 19 were participants who had a SARS-CoV-2 infection p values (p = 0.02–0.03). Thus, we did not interpret these as clinically significant, leading to the conclusion that young and otherwise healthy individuals (mainly men) seem to recover from mild COVID-19 infections with no ophthalmological residues.
