Cardiac hypertrophy and IGF-1 response to testosterone propionate treatment in trained male rats

Abstract

Several studies have suggested that testosterone exerts a growth-promoting effect in the heart. Limited data are available regarding interactions between possible endocrine/paracrine effects in response to exercise training. Therefore, we examined supraphysiological testosterone-induced heart hypertrophy and cardiac insulin-like growth factor (IGF)-1 content in sedentary and exercise-trained rats.

Keywords

• heart
• growth factors
• anabolic steroids
• exercise training