Nature Communications (Sep 2022)
Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks
Abstract
The proliferation of large biobanks necessitates statistical methods designed for genetic analysis on biobank data. Here, the authors have developed a frailty model-based method for GWAS analysis of time-to-event phenotypes in large biobanks that accounts for relatedness in samples and censoring of phenotypes.