Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality

• Zhengnian Li,
• Jie Jiang,
• Scott B. Ficarro,
• Tyler S. Beyett,
• Ciric To,
• Isidoro Tavares,
• Yingde Zhu,
• Jiaqi Li,
• Michael J. Eck,
• Pasi A. Jänne,
• Jarrod A. Marto,
• Tinghu Zhang,
• Jianwei Che,
• Nathanael S. Gray

Affiliations

Zhengnian Li

Department of Chemical and Systems Biology, Stanford Cancer Institute, ChEM-H, Stanford University, Stanford, California, United States

Jie Jiang

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Scott B. Ficarro

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Tyler S. Beyett

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Ciric To

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Isidoro Tavares

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Yingde Zhu

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Jiaqi Li

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Michael J. Eck

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Pasi A. Jänne

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Jarrod A. Marto

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Tinghu Zhang

Department of Chemical and Systems Biology, Stanford Cancer Institute, ChEM-H, Stanford University, Stanford, California, United States

Jianwei Che

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Nathanael S. Gray

Department of Chemical and Systems Biology, Stanford Cancer Institute, ChEM-H, Stanford University, Stanford, California, United States