Mapping RNA–RNA interactome and RNA structure in vivo by MARIO

Tri C. Nguyen; Xiaoyi Cao; Pengfei Yu; Shu Xiao; Jia Lu; Fernando H. Biase; Bharat Sridhar; Norman Huang; Kang Zhang; Sheng Zhong

doi:10.1038/ncomms12023

Nature Communications (Jun 2016)

Mapping RNA–RNA interactome and RNA structure in vivo by MARIO

Tri C. Nguyen,
Xiaoyi Cao,
Pengfei Yu,
Shu Xiao,
Jia Lu,
Fernando H. Biase,
Bharat Sridhar,
Norman Huang,
Kang Zhang,
Sheng Zhong

Affiliations

Tri C. Nguyen: Department of Bioengineering, University of California, San Diego
Xiaoyi Cao: Department of Bioengineering, University of California, San Diego
Pengfei Yu: Department of Bioengineering, University of California, San Diego
Shu Xiao: Department of Bioengineering, University of California, San Diego
Jia Lu: Department of Bioengineering, University of California, San Diego
Fernando H. Biase: Department of Bioengineering, University of California, San Diego
Bharat Sridhar: Department of Bioengineering, University of California, San Diego
Norman Huang: Department of Bioengineering, University of California, San Diego
Kang Zhang: Department of Ophthalmology, University of California, San Diego
Sheng Zhong: Department of Bioengineering, University of California, San Diego

DOI: https://doi.org/10.1038/ncomms12023
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Current methods for mapping RNA-RNA interactions have to rely on an ‘anchor’ protein or RNA. Here, the authors report the MARIO (Mapping RNA interactome in vivo) technology that can massively reveal RNA-RNA interactions and RNA structure from unperturbed cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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