Comparative analgesic efficacy for intraperitoneal administration of bupivacaine, ropivacaine, and ropivacaine-tizanidine combination during ovariohysterectomy of cats suffering from pyometritis

Abstract

A prospective clinical trial was conducted on 30 cats suffering from pyometritis to investigate the multimodal analgesic efficacy of ropivacaine-tizanidine (RT) combination through intraperitoneal (IP) administration during ovariohysterectomy. Cats were randomly assigned into three groups whereby group RT received 0.5% ropivacaine (1 mg/kg) and tizanidine (10 μg/kg) (IP), group B received 0.5% bupivacaine (2 mg/kg) (IP), and group R received only 0.5% ropivacaine (1 mg/kg) (IP). It was observed that duration for anesthetic recovery (P<0.0001) and extubation time (P=0.0492) differed significantly for group RT. Body temperature and Pulse remained significantly higher in RT group at 1-, and 2-h postoperative intervals, specifically. Interactive Visual Analogue Scale (IVAS) and UNESP-Botucatu Multidimensional Composite Pain Scale (MCPS) scores were significantly lower for group RT at 6-, 8-, and 12-h time periods. Whereas, Mechanical nociceptive threshold (MNT) measurements differed significantly across 1 (P=0.0037), 4 (P=0.0013), 8 (P=0.0024) and 12-h (P=0.0258) time periods. The need for rescue analgesia and Serum cortisol concentrations, consistently remained significantly lower in group RT (P<0.0001). However, values for ALT, AST, ALP, BUN, and creatinine showed no significant differences among groups at 1-, 8-, and 24-h postoperative periods. The study concluded that the ropivacaine-tizanidine combination effectively reduced pain scores, delayed the need for rescue analgesia, and avoided adverse effects.

Keywords

• bupivacaine
• intraperitoneal instillation
• multimodal analgesia
• ropivacaine
• tizanidine
• unesp-botucatu multidimensional composite pain scale