Nature Communications (Sep 2019)
Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis
- Venkata Naga Srikanth Garikipati,
- Suresh Kumar Verma,
- Zhongjian Cheng,
- Dongming Liang,
- May M. Truongcao,
- Maria Cimini,
- Yujia Yue,
- Grace Huang,
- Chunlin Wang,
- Cindy Benedict,
- Yan Tang,
- Vandana Mallaredy,
- Jessica Ibetti,
- Laurel Grisanti,
- Sarah M. Schumacher,
- Erhe Gao,
- Sudarsan Rajan,
- Jeremy E. Wilusz,
- David Goukassian,
- Steven R. Houser,
- Walter J. Koch,
- Raj Kishore
Affiliations
- Venkata Naga Srikanth Garikipati
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Suresh Kumar Verma
- Division of Cardiovascular Diseases, Department of Medicine, The University of Alabama at Birmingham
- Zhongjian Cheng
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Dongming Liang
- Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine
- May M. Truongcao
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Maria Cimini
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Yujia Yue
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Grace Huang
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Chunlin Wang
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Cindy Benedict
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Yan Tang
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Vandana Mallaredy
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Jessica Ibetti
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Laurel Grisanti
- Department of Biomedical Sciences, University of Missouri
- Sarah M. Schumacher
- Lerner Research Institute, Cleveland Clinic
- Erhe Gao
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Sudarsan Rajan
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Jeremy E. Wilusz
- Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine
- David Goukassian
- Zena & Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Steven R. Houser
- Cardiovascular Research Center and Department of Physiology, Lewis Katz School of Medicine, Temple University
- Walter J. Koch
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- Raj Kishore
- Center for Translational Medicine, Lewis Katz School of Medicine, Temple University
- DOI
- https://doi.org/10.1038/s41467-019-11777-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Circular RNAs (circRNAs) are non-coding RNAs generated from pre-mRNAs of coding genes by the splicing machinery whose function in the heart is poorly understood. Here the authors show that AAV-mediated delivery of the circRNA circFndc3b prevents cardiomyocyte apoptosis, enhances angiogenesis, and attenuates LV dysfunction post-MI in mice by regulating FUS-VEGF-A signalling.
