A phylogenetic approach to study the evolution of somatic mutational processes in cancer

Sayaka Miura; Tracy Vu; Jiyeong Choi; Jeffrey P. Townsend; Sajjad Karim; Sudhir Kumar

doi:10.1038/s42003-022-03560-0

Communications Biology (Jun 2022)

A phylogenetic approach to study the evolution of somatic mutational processes in cancer

Sayaka Miura,
Tracy Vu,
Jiyeong Choi,
Jeffrey P. Townsend,
Sajjad Karim,
Sudhir Kumar

Affiliations

Sayaka Miura: Institute for Genomics and Evolutionary Medicine, Temple University
Tracy Vu: Institute for Genomics and Evolutionary Medicine, Temple University
Jiyeong Choi: Institute for Genomics and Evolutionary Medicine, Temple University
Jeffrey P. Townsend: Program in Computational Biology and Bioinformatics, Yale University
Sajjad Karim: Center for Excellence in Genomic Medicine Research, King Abdulaziz University
Sudhir Kumar: Institute for Genomics and Evolutionary Medicine, Temple University

DOI: https://doi.org/10.1038/s42003-022-03560-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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A method, PhyloSignare, is presented to infer mutational signatures along a tumour evolutionary tree and is used to analyse somatic genomic variations in 61 lung cancer patients, providing insights into tumour evolution.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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