A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA

Kevin Van Bortle; David P. Marciano; Qing Liu; Tristan Chou; Andrew M. Lipchik; Sanjay Gollapudi; Benjamin S. Geller; Emma Monte; Rohinton T. Kamakaka; Michael P. Snyder

doi:10.1038/s41467-022-30323-6

Nature Communications (May 2022)

A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA

Kevin Van Bortle,
David P. Marciano,
Qing Liu,
Tristan Chou,
Andrew M. Lipchik,
Sanjay Gollapudi,
Benjamin S. Geller,
Emma Monte,
Rohinton T. Kamakaka,
Michael P. Snyder

Affiliations

Kevin Van Bortle: Department of Genetics, Stanford University
David P. Marciano: Department of Genetics, Stanford University
Qing Liu: Department of Genetics, Stanford University
Tristan Chou: Department of Genetics, Stanford University
Andrew M. Lipchik: Department of Genetics, Stanford University
Sanjay Gollapudi: Genomics Research Internship Program at Stanford, Stanford University
Benjamin S. Geller: Department of Genetics, Stanford University
Emma Monte: Department of Genetics, Stanford University
Rohinton T. Kamakaka: Department of Molecular, Cell, and Developmental Biology, University of Santa Cruz
Michael P. Snyder: Department of Genetics, Stanford University

DOI: https://doi.org/10.1038/s41467-022-30323-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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RNA polymerase III changes its subunit composition during mammalian development. Here the authors report that loss of subunit POLR3G, which re-emerges in cancer, promotes expression of small NF90-associated RNA (snaR-A), a noncoding RNA implicated in cell proliferation and metastasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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