Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection

Abstract

Malhi et al. conduct a high-throughput screen to identify inhibitors of respiratory syncytial virus (RSV). They find that statins inhibit post-entry events in the replicative cycle of RSV through a combination of cholesterol and isoprenoid-mediated effects, the latter involving a loss of Rho GTPase activity via disruption of protein prenylation.