Clinical Application of Cardiac Magnetic Resonance in ART-Treated AIDS Males with Short Disease Duration
Keke Hou,
Hang Fu,
Wei Xiong,
Yueqin Gao,
Liqiu Xie,
Jianglin He,
Xianbiao Feng,
Tao Zeng,
Lin Cai,
Lei Xiong,
Nan Jiang,
Min Jiang,
Bin Kang,
Haiyan Zheng,
Na Zhang,
Yingkun Guo
Affiliations
Keke Hou
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Hang Fu
Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Department of Radiology, West China Second University Hospital, Sichuan University, 20# South Renmin Road, Chengdu 610017, China
Wei Xiong
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Yueqin Gao
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Liqiu Xie
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Jianglin He
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Xianbiao Feng
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Tao Zeng
Department of Ultrasound, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Lin Cai
Department of Infectious Disease, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Lei Xiong
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Nan Jiang
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Min Jiang
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Bin Kang
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Haiyan Zheng
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Na Zhang
Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu 610061, China
Yingkun Guo
Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Department of Radiology, West China Second University Hospital, Sichuan University, 20# South Renmin Road, Chengdu 610017, China
Cardiac complications are common in antiretroviral therapy-treated (ART-treated) acquired immune deficiency syndrome (AIDS) patients, and the incidence increases with age. Myocardial injury in ART-treated AIDS patients with a relatively longer disease duration has been evaluated. However, there is no relevant study on whether patients with a short AIDS duration have cardiac dysfunction. Thirty-seven ART-treated males with AIDS and eighteen healthy controls (HCs) were prospectively included for CMR scanning. Clinical data and laboratory examination results were collected. The ART-treated males with AIDS did not have significantly reduced biventricular ejection fraction, myocardial edema, or late gadolinium enhancement. Compared with the HCs, the biventricular volume parameters and left ventricle myocardial strain indices in ART-treated males with AIDS were not significantly reduced (all p > 0.05). ART-treated males with AIDS were divided into subgroups according to their CD4+ T-cell counts (p > 0.05). In Pearson correlation analysis, CD4+ T-cell counts were not significantly correlated with biventricular volume parameters or left ventricular myocardial strain indices. In conclusion, ART-treated males with AIDS receiving ART therapy with a short disease duration (less than 3 years) might not develop obvious cardiac dysfunction as evaluated by routine CMR, so it is reasonable to appropriately extend the interval between cardiovascular follow-ups to more than 3 years.
