A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division

Silvia Martini; Khalil Davis; Rupert Faraway; Lisa Elze; Nicola Lockwood; Andrew Jones; Xiao Xie; Neil Q. McDonald; David J. Mann; Alan Armstrong; Jernej Ule; Peter J. Parker

doi:10.1038/s41467-021-27189-5

Nature Communications (Nov 2021)

A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division

Silvia Martini,
Khalil Davis,
Rupert Faraway,
Lisa Elze,
Nicola Lockwood,
Andrew Jones,
Xiao Xie,
Neil Q. McDonald,
David J. Mann,
Alan Armstrong,
Jernej Ule,
Peter J. Parker

Affiliations

Silvia Martini: Protein Phosphorylation Laboratory, The Francis Crick Institute
Khalil Davis: Protein Phosphorylation Laboratory, The Francis Crick Institute
Rupert Faraway: RNA Network Laboratory, The Francis Crick Institute
Lisa Elze: Department of Human Genetics, Radboud University Medical Center
Nicola Lockwood: Protein Phosphorylation Laboratory, The Francis Crick Institute
Andrew Jones: Cell Cycle Laboratory, The Francis Crick Institute
Xiao Xie: Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University
Neil Q. McDonald: Signalling and Structural Biology Laboratory, The Francis Crick Institute
David J. Mann: Department of Life Sciences, Imperial College London
Alan Armstrong: Department of Chemistry, Imperial College
Jernej Ule: RNA Network Laboratory, The Francis Crick Institute
Peter J. Parker: Protein Phosphorylation Laboratory, The Francis Crick Institute

DOI: https://doi.org/10.1038/s41467-021-27189-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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PKCε is known to exert a role in genome protection by directly phosphorylating and switching the specificity of Aurora B. Here the authors identify SERBP1 as a parallel mitotic PKCε substrate controlling translation and ensuring the integrity of chromosome segregation and successful cell division.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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