Inferring structural variant cancer cell fraction

Affiliations

Marek Cmero: Department of Surgery, Division of Urology, Royal Melbourne Hospital and University of Melbourne
Ke Yuan: School of Computing Science, University of Glasgow, Sir Alwyn Williams Building
Cheng Soon Ong: Electrical and Electronic Engineering, University of Melbourne
Jan Schröder: Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research
PCAWG Evolution and Heterogeneity Working Group
Niall M. Corcoran: Department of Surgery, Division of Urology, Royal Melbourne Hospital and University of Melbourne
Tony Papenfuss: Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research
Christopher M. Hovens: Department of Surgery, Division of Urology, Royal Melbourne Hospital and University of Melbourne
Florian Markowetz: Cancer Research UK Cambridge Institute, University of Cambridge
Geoff Macintyre: Department of Computing and Information Systems, University of Melbourne
PCAWG Consortium

Abstract

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.