Nature Communications (Nov 2021)

Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures

  • Hongxu Ding,
  • Ioannis Anastopoulos,
  • Andrew D. Bailey,
  • Joshua Stuart,
  • Benedict Paten

DOI
https://doi.org/10.1038/s41467-021-26929-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Nanopore sequencing allows users to identify nucleotide sequence from ionic currents. Here, the authors use deep learning to facilitate the de novo identification of modified nucleotides, particularly methylated cytosine and guanine, from the measured ionic currents without the need for controls.