Impact of DNA methylation on 3D genome structure

Diana Buitrago; Mireia Labrador; Juan Pablo Arcon; Rafael Lema; Oscar Flores; Anna Esteve-Codina; Julie Blanc; Nuria Villegas; David Bellido; Marta Gut; Pablo D. Dans; Simon C. Heath; Ivo G. Gut; Isabelle Brun Heath; Modesto Orozco

doi:10.1038/s41467-021-23142-8

Nature Communications (May 2021)

Impact of DNA methylation on 3D genome structure

Diana Buitrago,
Mireia Labrador,
Juan Pablo Arcon,
Rafael Lema,
Oscar Flores,
Anna Esteve-Codina,
Julie Blanc,
Nuria Villegas,
David Bellido,
Marta Gut,
Pablo D. Dans,
Simon C. Heath,
Ivo G. Gut,
Isabelle Brun Heath,
Modesto Orozco

Affiliations

Diana Buitrago: Institute for Research in Biomedicine (IRB Barcelona) - The Barcelona Institute of Science and Technology (BIST)
Mireia Labrador: Institute for Research in Biomedicine (IRB Barcelona) - The Barcelona Institute of Science and Technology (BIST)
Juan Pablo Arcon: Institute for Research in Biomedicine (IRB Barcelona) - The Barcelona Institute of Science and Technology (BIST)
Rafael Lema: Institute for Research in Biomedicine (IRB Barcelona) - The Barcelona Institute of Science and Technology (BIST)
Oscar Flores: Institute for Research in Biomedicine (IRB Barcelona) - The Barcelona Institute of Science and Technology (BIST)
Anna Esteve-Codina: CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
Julie Blanc: CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
Nuria Villegas: Institute for Research in Biomedicine (IRB Barcelona) - The Barcelona Institute of Science and Technology (BIST)
David Bellido: Centres Cientifics i Tecnologics, Universitat de Barcelona
Marta Gut: CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
Pablo D. Dans: Institute for Research in Biomedicine (IRB Barcelona) - The Barcelona Institute of Science and Technology (BIST)
Simon C. Heath: CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
Ivo G. Gut: CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
Isabelle Brun Heath: Institute for Research in Biomedicine (IRB Barcelona) - The Barcelona Institute of Science and Technology (BIST)
Modesto Orozco: Institute for Research in Biomedicine (IRB Barcelona) - The Barcelona Institute of Science and Technology (BIST)

DOI: https://doi.org/10.1038/s41467-021-23142-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Multi-layered epigenetic regulation in higher eukaryotes makes it challenging to disentangle the individual effects of modifications on chromatin structure and function. Here, the authors expressed mammalian DNA methyltransferases in yeast, which have no DNA methylation, to show that methylation has intrinsic effects on chromatin structure.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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