Structure-Based Engineering of Monoclonal Antibodies for Improved Binding to Counteract the Effects of Fentanyl and Carfentanil

• Justas Rodarte,
• Carly Baehr,
• Dustin Hicks,
• Morgan McGovern,
• Yue Zhang,
• Pedro Silva-Ortiz,
• Bryan Hannon,
• Sowmya Duddu,
• Marie Pancera,
• Marco Pravetoni

Affiliations

Justas Rodarte

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States

Carly Baehr

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States

Dustin Hicks

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States

Morgan McGovern

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States

Yue Zhang

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States

Pedro Silva-Ortiz

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States

Bryan Hannon

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States

Sowmya Duddu

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States

Marie Pancera

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States

Marco Pravetoni

Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle, Washington, United States