Cell Reports (Jul 2017)

The Lifespan and Turnover of Microglia in the Human Brain

  • Pedro Réu,
  • Azadeh Khosravi,
  • Samuel Bernard,
  • Jeff E. Mold,
  • Mehran Salehpour,
  • Kanar Alkass,
  • Shira Perl,
  • John Tisdale,
  • Göran Possnert,
  • Henrik Druid,
  • Jonas Frisén

DOI
https://doi.org/10.1016/j.celrep.2017.07.004
Journal volume & issue
Vol. 20, no. 4
pp. 779 – 784

Abstract

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The hematopoietic system seeds the CNS with microglial progenitor cells during the fetal period, but the subsequent cell generation dynamics and maintenance of this population have been poorly understood. We report that microglia, unlike most other hematopoietic lineages, renew slowly at a median rate of 28% per year, and some microglia last for more than two decades. Furthermore, we find no evidence for the existence of a substantial population of quiescent long-lived cells, meaning that the microglia population in the human brain is sustained by continuous slow turnover throughout adult life.

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