Synthetic treatment of intracranial peripheral primitive neuroectodermal tumor with multiple metastasis: a case report

Abstract

Yang Zhang,1,2 Hongsheng Li,2 Zongjuan Li,3 Ming Liu,1,2 Linke Yang,2 Liyuan Fan,2 Chengsuo Huang,2 Baosheng Li21School of Medicine and Life Sciences, Jinan University-Shandong Academy of Medical Sciences, 2Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, 3Department of Radiation Oncology, The Second Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of ChinaAbstract: Ewing sarcomas (ES) and peripheral primitive neuroectodermal tumors (pPNET) are now thought to belong to the same tumor family. Ewing sarcoma family tumor (ESFT) members commonly originate in bones and soft tissues. However, a few published articles describe ESFT arising from cranial cavities. Pathologically, ES/pPNET are composed of small round cells. Unambiguous distinction between pPNET and other small round cell tumors, in particular central PNET, is of clinical significance. Definitive diagnoses of pPNET can be obtained through CD99 (MIC2 gene product) membrane positivities and molecular identifications of chromosomal rearrangements between EWS and ETS family genes. Multimodal approaches comprising surgical resections, radiotherapies, and chemotherapies are required for the treatment of ESFT. Decompressive medical measures are preferentially performed when epidural masses are compressing spinal cords. In cases of ES-induced brain herniations, emergent radiotherapies may serve as effective tools. We report a case of multiple disseminated intracranial ES/pPNET for which synthetic treatments were used.Keywords: primitive neuroectodermal tumors, brain neoplasms, spinal tumors, neoplasm metastases

Keywords

• primitive neuroectodermal tumors
• brain neoplasms
• spinal tumors
• neoplasm metastases