Journal of Pharmacopuncture (Mar 2010)
Anticancer effect of mountain ginseng Pharmacopuncture to the nude mouse of lung carcinoma induced by NCI-H460 human non-small cell lung cancer cells
Abstract
Objectives :This study was performed to examine the anticancer effect of mountain ginsengPharmacopuncture(MGP) to the nude mouse of lung carcinoma induced by NCI-H460 human nonsmalllung cancer cells. Methods :Human lung cancer (NCI-H460) cells were cultured and applied to evaluate anti-tumoractivity in nude mice. After confirmed tumor growth in mice, MGP was treated per 0.1ml/kg dose tointraperitoneal and intravenous injection everyday for four weeks. And checked the changes in bodyweights, tumor volume, mean survival time and percent, increase in life span, histo-pathological findings,organ weights, and blood chemistry levels. Results :The results of in vivo study showed that MGP may have potential as growth inhibitor of solid tumor induced NCI-H460 without marked side effects. MGP inhibited dosage-dependently the growth of NCI-H460 cell-transplanted solid tumor compared with the control group. And mean survival time of MGP treated group was prolonged comparing with control group. Generally the group of intravenous injection is more effective than intraperitoneal injection. Conclusion :These results were suggested that MGP may be a useful anticancer agent for therapy of human lung cancer. And follow study need for the certain evidence.
Keywords
