Nature Communications (Oct 2021)
Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology
- Alessandra Stangherlin,
- Joseph L. Watson,
- David C. S. Wong,
- Silvia Barbiero,
- Aiwei Zeng,
- Estere Seinkmane,
- Sew Peak Chew,
- Andrew D. Beale,
- Edward A. Hayter,
- Alina Guna,
- Alison J. Inglis,
- Marrit Putker,
- Eline Bartolami,
- Stefan Matile,
- Nicolas Lequeux,
- Thomas Pons,
- Jason Day,
- Gerben van Ooijen,
- Rebecca M. Voorhees,
- David A. Bechtold,
- Emmanuel Derivery,
- Rachel S. Edgar,
- Peter Newham,
- John S. O’Neill
Affiliations
- Alessandra Stangherlin
- MRC Laboratory of Molecular Biology
- Joseph L. Watson
- MRC Laboratory of Molecular Biology
- David C. S. Wong
- MRC Laboratory of Molecular Biology
- Silvia Barbiero
- MRC Laboratory of Molecular Biology
- Aiwei Zeng
- MRC Laboratory of Molecular Biology
- Estere Seinkmane
- MRC Laboratory of Molecular Biology
- Sew Peak Chew
- MRC Laboratory of Molecular Biology
- Andrew D. Beale
- MRC Laboratory of Molecular Biology
- Edward A. Hayter
- Faculty of Biology, Medicine and Health, University of Manchester
- Alina Guna
- UCSF
- Alison J. Inglis
- California Institute of Technology
- Marrit Putker
- MRC Laboratory of Molecular Biology
- Eline Bartolami
- Department of Chemistry, University of Geneva
- Stefan Matile
- Department of Chemistry, University of Geneva
- Nicolas Lequeux
- LPEM - ESPCI Paris, PSL, CNRS, Sorbonne Université
- Thomas Pons
- LPEM - ESPCI Paris, PSL, CNRS, Sorbonne Université
- Jason Day
- Department of Earth Sciences, University of Cambridge
- Gerben van Ooijen
- School of Biological Sciences, University of Edinburgh
- Rebecca M. Voorhees
- California Institute of Technology
- David A. Bechtold
- Faculty of Biology, Medicine and Health, University of Manchester
- Emmanuel Derivery
- MRC Laboratory of Molecular Biology
- Rachel S. Edgar
- Department of Infectious Diseases, Imperial College London
- Peter Newham
- Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca
- John S. O’Neill
- MRC Laboratory of Molecular Biology
- DOI
- https://doi.org/10.1038/s41467-021-25942-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Osmotic compensation by electroneutral ion transport buffers TORC1-mediated changes in the cytosolic proteome, and maintains intracellular homeostasis and cell volume over the circadian cycle. Here, the authors find such ion content changes drive daily rhythms in cardiomyocyte electrical activity.
