Nature Communications (Nov 2021)

A structured RNA motif locks Argonaute2:miR-122 onto the 5’ end of the HCV genome

  • Luca F. R. Gebert,
  • Mansun Law,
  • Ian J. MacRae

DOI
https://doi.org/10.1038/s41467-021-27177-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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The RNA genome of the Hepatitis C Virus binds to the liver-specific miR122. Here the authors report the crystal structure of the Ago2:miR122:HCV complex showing that the viral RNA’s structural element traps the Ago2:miR-122 complex on the 5’ end of the viral genome to protect it from degradation.