Functions of mucosal associated invariant T cells in eye diseases

Chihiro Fukui; Satoshi Yamana; Yanqi Xue; Mariko Shirane; Hiroki Tsutsui; Kenichiro Asahara; Keiko Yoshitomi; Takako Ito; Tantri Lestari; Eiichi Hasegawa; Nobuyo Yawata; Atsunobu Takeda; Koh-Hei Sonoda; Kensuke Shibata; Kensuke Shibata; Kensuke Shibata

doi:10.3389/fimmu.2024.1341180

Frontiers in Immunology (Feb 2024)

Functions of mucosal associated invariant T cells in eye diseases

Chihiro Fukui,
Satoshi Yamana,
Yanqi Xue,
Mariko Shirane,
Hiroki Tsutsui,
Kenichiro Asahara,
Keiko Yoshitomi,
Takako Ito,
Tantri Lestari,
Eiichi Hasegawa,
Nobuyo Yawata,
Atsunobu Takeda,
Koh-Hei Sonoda,
Kensuke Shibata,
Kensuke Shibata,
Kensuke Shibata

Affiliations

Chihiro Fukui: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Satoshi Yamana: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Yanqi Xue: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mariko Shirane: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hiroki Tsutsui: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Kenichiro Asahara: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Keiko Yoshitomi: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Takako Ito: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Tantri Lestari: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Eiichi Hasegawa: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Nobuyo Yawata: Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Atsunobu Takeda: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Koh-Hei Sonoda: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Kensuke Shibata: Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Kensuke Shibata: Department of Microbiology and Immunology, Graduate School of Medicine, Yamaguchi University, Ube, Japan
Kensuke Shibata: Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan

DOI: https://doi.org/10.3389/fimmu.2024.1341180
Journal volume & issue: Vol. 15

Abstract

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Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells in cancer, autoimmunity, and infectious diseases has been rapidly expanding. Recently, MAIT cells have been found to contribute to visual protection against autoimmunity in the eye. The protective functions of MAIT cells are induced by T-cell receptor (TCR)-mediated activation. However, the underlying mechanisms remain unclear. Thus, this mini-review aims to discuss our findings and the complexity of MAIT cell-mediated immune regulation in the eye.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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