Communications Biology (Apr 2021)
ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
- Su Chul Jang,
- Kyriakos D. Economides,
- Raymond J. Moniz,
- Chang Ling Sia,
- Nuruddeen Lewis,
- Christine McCoy,
- Tong Zi,
- Kelvin Zhang,
- Rane A. Harrison,
- Joanne Lim,
- Joyoti Dey,
- Marc Grenley,
- Katherine Kirwin,
- Nikki L. Ross,
- Raymond Bourdeau,
- Agata Villiger-Oberbek,
- Scott Estes,
- Ke Xu,
- Jorge Sanchez-Salazar,
- Kevin Dooley,
- William K. Dahlberg,
- Douglas E. Williams,
- Sriram Sathyanarayanan
Affiliations
- Su Chul Jang
- Codiak BioSciences Inc.
- Kyriakos D. Economides
- Codiak BioSciences Inc.
- Raymond J. Moniz
- Codiak BioSciences Inc.
- Chang Ling Sia
- Codiak BioSciences Inc.
- Nuruddeen Lewis
- Codiak BioSciences Inc.
- Christine McCoy
- Codiak BioSciences Inc.
- Tong Zi
- Codiak BioSciences Inc.
- Kelvin Zhang
- Codiak BioSciences Inc.
- Rane A. Harrison
- Codiak BioSciences Inc.
- Joanne Lim
- Codiak BioSciences Inc.
- Joyoti Dey
- Presage Biosciences
- Marc Grenley
- Presage Biosciences
- Katherine Kirwin
- Codiak BioSciences Inc.
- Nikki L. Ross
- Codiak BioSciences Inc.
- Raymond Bourdeau
- Codiak BioSciences Inc.
- Agata Villiger-Oberbek
- Codiak BioSciences Inc.
- Scott Estes
- Codiak BioSciences Inc.
- Ke Xu
- Codiak BioSciences Inc.
- Jorge Sanchez-Salazar
- Codiak BioSciences Inc.
- Kevin Dooley
- Codiak BioSciences Inc.
- William K. Dahlberg
- Codiak BioSciences Inc.
- Douglas E. Williams
- Codiak BioSciences Inc.
- Sriram Sathyanarayanan
- Codiak BioSciences Inc.
- DOI
- https://doi.org/10.1038/s42003-021-02004-5
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 17
Abstract
Su Chul Jang et al. develop exoSTING, consisting of an engineered extracellular vesicle loaded with a potent cyclic dinucleotide (CDN) agonist of the STING pathway. They find that exoSTING shows more than 100-fold increased potency in in vivo tumor models and has increased tumor retention and lower levels of systemic inflammatory cytokine production as compared to free CDN.
