Communications Chemistry (Jan 2023)

Directly imaging emergence of phase separation in peroxidized lipid membranes

  • Miguel Paez-Perez,
  • Aurimas Vyšniauskas,
  • Ismael López-Duarte,
  • Eulalie J. Lafarge,
  • Raquel López-Ríos De Castro,
  • Carlos M. Marques,
  • André P. Schroder,
  • Pierre Muller,
  • Christian D. Lorenz,
  • Nicholas J. Brooks,
  • Marina K. Kuimova

DOI
https://doi.org/10.1038/s42004-022-00809-x
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 10

Abstract

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Lipid peroxidation plays an important role in cell signaling and disease as well as therapy, however, the effect on the membrane structure and mechanical behavior remains poorly understood. Here, the authors report the direct and quantitative measurement of the bilayer’s structure and viscoelastic properties upon peroxidation of lipid membranes.