The impact of inflammation on Resistin, Insulin and Troponin I in Acute Myocardial Infarction patients

Abstract

Background: Myocardial Infarction (MI) is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue may play an important role in mediating this chronic inflammatory process. Inflammatory responses are involved in the initiation and progression of atherosclerotic plaques. Resistin is a cysteine-rich polypeptide that is expressed at relatively lower levels in human adipocytes but higher levels in macrophages. Insulin is an important hormone as it regulates the level of glucose, in the blood. This protein is formed in specialized cells of the pancreas called beta islet cells. Subjects and Methods:The study included 50 patients with AMI and fourty healthy subjects as controls. levels of resistin, insulin and troponin were measured. Results: The levels of resistin and insulin were significantly elevated with (p<0.001), there was a positive correlation between resistin with insulin and troponin in acute myocardial infarction. Conclusions: There was a significant increase in the levels of resistin, in acute myocardial infarction patients and this increase may be related to inflammation. Elevated levels of resistin can lead to glucose intolerance in AMI patients.

Keywords

• Resistin, Insulin, Troponin I and Acute Myocardial Infarction.